Marian KoshlandDied 28 Oct 1997 at age 76 (born 25 Oct 1921). American immunologist who discovered that the differences in amino acid composition of antibodies explains the efficiency and effectiveness with which they combat a huge range of foreign invaders. During WWII, her post-graduate studies included assisting with projects developing an Asiatic cholera vaccine, and combatting transmission of airborne pathogens in army barracks. In 1970 she became a professor of Microbiology and Immunology, after which she discovered the J chain (a B cell antibody subunit). In 1991, with colleagues, she identified a specialized intracellular pathway that transports antibodies into blood circulation, allowing for the multiplication of B cells essential in fighting infection.«* |
