Harold VarmusBorn 18 Dec 1939.American virologist who shared, with J. Michael Bishop, the 1989 Nobel Prize for Physiology or Medicine for their work on the origins of cancer - that cancer genes (oncogenes) can arise from normal cellular genes, called proto-oncogenes. Oncogenes are normal genes that control growth in every living cell, but which under certain conditions can turn renegade and cancerous. They believed that the growth of cancerous cells is not the result of an invasion from outside the cell, but rather a misuse of a normal gene by a retrovirus, as a result of exposure to some aggravating carcinogen, such as radiation or smoke. Their research in the mid '70s has led to great strides in the understanding, diagnosis, and treatment of a variety of cancers. |
