Oskar HertwigDied 25 Oct 1922 at age 73 (born 21 Apr 1849). Oskar (Wilhelm August) Hertwig was a German embryologist and cytologist who did extensive work on the nuclear transmission of heredity. He was the first to recognize that the essential event in fertilization is the fusion of the nuclei of the sperm and ovum. In 1875, he observed all the steps in fertilization, including the union of egg and sperm chromosomes in sea urchins. These animals are particularly suitable for microscopic studies because of their transparency. He saw there was a single nucleus before fertilization and two nuclei immediately afterwards. He realized the second nucleus had come from the spermatazoon, and thus a single spermatazoon can fertilize an egg. He also investigated malformations of vertebrate embryos. |