William Cumming RoseBorn 4 Apr 1887; died 25 Sep 1985 at age 98.American biochemist who researched the role of amino acids in nutrition determining which were essential, and calculated the minimum daily requirement for each of them. Having found that the milk protein, casein, was essential in a healthy rat's diet, he discovered (1936) the threonine in the casein was an essential amino acid. Over several years he manipulated the rodent diet and finally established the primary importance of nine more amino acids: lysine, tryptophan, histidine, phenylalanine, leucine, isoleucine, methionine, valine, and arginine. In 1942, Rose began a ten-year research project on human diet. By persuading students to restrict their diet in various ways Rose eventually established that 8 of the above are essential amino acids for adults. |
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