NicotineIn 1998, scientists announced the identification for the first time of a key brain chemical related to nicotine addiction, in the journal Nature. The researchers worked at the Pasteur Institute in Paris, Karolinska Institute in Stockholm and the research arm of Glaxo-Wellcome in Geneva. The addictive nature of nicotine is related to release of dopamine, a neurotransmitter chemical in the brain. The scientists had found the first of 11 subunits, or molecules, of the nicotine receptor in the brain of mice. Mutant mice lacking the b2 subunit in their brains did not react to nicotine. Humans have the same so-called b2 subunit. This is a step toward to designing a drug to block the receptor, and produce new smoking-cessation drugs.« |
