“My door was ajar, so I added jelly, now it's a door jam.”
Irwin RoseBorn 16 Jul 1926.American biochemist who was a awarded a share of the 2004 Nobel Prize in Chemistry (with Israelis Aaron Ciechanover and Avram Hershko) for discovering the role of the protein ubiquitin in cells. This small protein molecule attaches to other proteins, tagging them for removal, which are thus recognized by the cell's proteasomes. These structures are the cell's waste-disposal units, where the proteins are broken down into tiny pieces for reuse. This ubiquitin-mediated process cleans up unwanted proteins resulting during cell division, and performs quality control on newly synthesized proteins. Faulty protein-breakdown processes lead to such conditions as cystic fibrosis, several neurodegenerative diseases, and certain types of cancer.« |
