Lewis Hastings SarettBorn 22 Dec 1917; died 29 Nov 1999 at age 81.American organic chemist who prepared a synthetic version of the hormone cortisone (1944) using a complicated 36-step process. He was a research scientist (1942-48) at Merck & Co., Inc. Four years later the Mayo Clinic demonstrated the efficacy of the product against rheumatoid arthritis. Cortisone also has wide-ranging applications in the treatment of allergies as well as inflammatory and neoplastic diseases. In 1949, Sarett and several collaborators initiated an alternative synthesis commencing with raw materials derivable from coal, air, lime, and water. This led to the first route independent of naturally occurring starting materials. Sarett was the 1975 recipient of the National Medal of Science.« |
