Sir Aaron KlugBorn 11 Aug 1926. British biochemist who received the 1982 Nobel Prize for Chemistry "for his development of crystallographic electron microscopy and his structural elucidation of biologically important nucleic acid-protein complexes." Whereas X-ray diffraction patterns reveal any highly ordered three-dimensional crystalline structures, the technique fails for those biological samples with less suitably ordered molecular structures. However Klug developed crystallographic electron microscopy which combined certain principles of the diffraction methods with electron miscroscopy so that he could figure out the 3-D structure of viruses or samples of complicated combinations of nucleic acids and proteins as found in membranes, muscle fibres and chromosomes.« |
